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Melda’s Eye Disease and the Search for a Diagnosis
Updated 28 September 2026 Melda is 12 years old and has lived with recurrent inflammation and scarring of the conjunctiva in both eyes since early childhood. The first adhesion between the eyelid and the eye appeared in her right eye in November 2016. A similar adhesion developed in her left eye shortly afterwards. Both were present before her only ocular biopsy, performed in April 2017. The disease has fluctuated over the years. At one point, the right eye became quiet while the left eye continued to flare. Repeated damage to the left cornea has led to severely reduced vision. In September 2026, the right eye developed a serious flare with…
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Reactions physicians after studying Melda’s files
When I searched the literature I came across cases of severe eye allergy and vernal conjunctivitis associated with this condition. Both allergic and autoimmune/rheumatic conditions can be of influence. Birch sensitivity appeared in the ISAC test for allergy. Blood results for autoimmune and rheumatic tests also look normal. TOM1 gene mutation can cause immune deficiency. There is a predisposition for immunodeficiency in TOM1 gene My suggestion is: - Repeat studies made - Additional immune system tests: eg looking at vaccine responses and lymphocyte subsets. - If she does not have frequent infections and her development is good for her age, these tests (with what we will do in addition) are…