Splendore-Hoeppli Phenomenon

When I searched the literature I came across cases of severe eye allergy and vernal conjunctivitis associated with this condition. Both allergic and autoimmune/rheumatic conditions can be of influence. Birch sensitivity appeared in the ISAC test for allergy. Blood results for autoimmune and rheumatic tests also look normal. TOM1 gene mutation can cause immune deficiency. There is a predisposition for immunodeficiency in TOM1 gene My suggestion is: - Repeat studies made - Additional immune system tests: eg looking at vaccine responses and lymphocyte subsets. - If she does not have frequent infections and her development is good for her age, these tests (with what we will do in addition) are…

We have an 8-year-old daughter named Melda who lives in The Hague, Netherlands. Melda has been experiencing symptoms such as scar redness, pain and swelling in her eyes from time to time for 5 years. The sighting rate also decreased to 20 percent during this time. She is under the supervision of the best pediatric opthalmologists in the Netherlands. Symptoms have been evaluated for 5 years under the leadership of Prof. Dr. Nicoline Schalij-Delfos. They also communicate with other ophthalmologists around the world, but unfortunately, a definitive diagnosis could not be made.  They suspected the *splendore hoeppli phenomenon*. We gave Melda Tacrolimus (from April 2020 untill june 2021). First this medicine…

Splendore-Hoeppli phenomenon (asteroid bodies) is the in vivo formation of intensely eosinophilic material (radiate, star-like, asteroid or club-shaped configurations) around microorganisms (fungi, bacteria and parasites) or biologically inert substances.  Available studies indicate that several mucocutaneous infections can generate Splendore-Hoeppli reaction. The fungal infections include sporotrichosis, pityrosporum folliculitis, zygomycosis, candidiasis, aspergillosis and blastomycosis. The bacterial infections include botryomycosis, nocardiosis and actinomycosis.